eBook Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products, 1st Edition

  • Published By:
  • ISBN-10: 3319011898
  • ISBN-13: 9783319011899
  • DDC: 615.7
  • Grade Level Range: College Freshman - College Senior
  • 216 Pages | eBook
  • Original Copyright 2014 | Published/Released June 2014
  • This publication's content originally published in print form: 2014
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About

Overview

Zacarías León's thesis describes the development and validation of analytical methods to estimate the processes set in motion by percutaneous absorption of UV filters in sunscreen cosmetic products. León describes these methods in both in vitro and non-invasive in vivo methodologies. Currently dermatologists recommend the use of sunscreen products not only under conditions of extreme exposure to the sun but also in daily situations. However the chemical compounds in these products contain may lead to undesired processes and cause induced toxicity, estrogenic effects and endocrine activity. León establishes methods to investigate these effects and provides valuable information on the undesired side effects associated with the use of UV filters found in sunscreen products. The work in this thesis has led to a number of publications in renowned analytical chemistry journals.

Table of Contents

Front Cover.
Half Title Page.
Aims and Scope.
Title Page.
Copyright Page.
Other Frontmatter.
Dedication.
Supervisors’ Foreword.
Contents.
1: Introduction.
2: Sunscreen Cosmetics: Advantages and Drawbacks.
3: In Vitro Methodology.
4: Development of a Chromatographic Method to Estimate the in Vitro Percutaneous Absorption of Hydrosoluble UV Filters.
5: In Vivo Methodology.
6: Determination of the Unconjugated Forms of Benzophenone-3 and Benzophenone-4 in Urine by Solid-Phase Extraction Coupled to a Liquid Chromatographic System with UV/Vis Detection by Using Automated Sequential Injection Analysis.
7: Determination of Benzophenone-3 and Their Metabolites in Urine by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry.
8: Determination of Benzophenone-3 and its Metabolites in Human Semen by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry.
9: Elucidation of the in Vitro Biotransformation Products of Ethylhexyl Dimethyl PABA by Chromatographic Techniques Coupled to Mass Spectrometry.
10: Elucidation of the in Vivo Biotransformation Products of Ethylhexyl Dimethyl PABA by Liquid Chromatographic Techniques with Mass Spectrometry Detectors.
11: Determination of Ethylhexyl Dimethyl PABA and its Metabolites in Semen by Automated Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry.
12: Determination of Methyl Benzylidene Camphor and its Main Metabolite in Urine by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry.
13: Summary and General Conclusions.
14: Highlights of the Ph.D. Thesis.
Annex I Keys Used.
Annex II Keys Used Protocols to Develop the Sunscreen Cosmetic Products Used in this Ph.D. Thesis.
Annex III Statistical Tests.