eBook Inhibitors of the Ras Superfamily G-proteins, Part B, 1st Edition

  • Volume 2
  • Published By:
  • ISBN-10: 012420211X
  • ISBN-13: 9780124202115
  • DDC: 572.696
  • Grade Level Range: College Freshman - College Senior
  • 280 Pages | eBook
  • Original Copyright 2014 | Published/Released June 2014
  • This publication's content originally published in print form: 2014
  • Price:  Sign in for price



Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes’ volumes that discuss inhibitors of the Ras superfamily G-proteins.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
1: Discovery of Small-Molecule Ras Inhibitors that Display Antitumor Activity by Interfering with Ras·GTP–Effector Interaction.
2: An Orthosteric Inhibitor of the RAS–SOS Interaction.
3: Conformation-Specific Inhibitors of Raf Kinases.
4: Inhibitors of the ERK Mitogen-Activated Protein Kinase Cascade for Targeting RAS Mutant Cancers.
5: Inhibiting the RAS–PI3K Pathway in Cancer Therapy.
6: The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras Cancers.
7: p21-Activated Kinase Inhibitors.
8: Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Toward Inhibiting K-Ras and N-Ras Functions.
9: Synthetic Lethal Genetic Screens in Ras Mutant Cancers.
Author Index.
Subject Index.