eBook Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 1st Edition

  • Volume 1
  • Published By:
  • ISBN-10: 0124055354
  • ISBN-13: 9780124055353
  • DDC: 571.655
  • Grade Level Range: College Freshman - College Senior
  • 360 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013
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About

Overview

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.

Table of Contents

Front Cover.
Title Page.
Copyright Page.
Dedication.
Acknowledgements.
Contents.
Preface.
Contributors.
List of Contributions Projected in Volumes 2-4.
Abbreviations and Glossary.
1: Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1-4.
2: General Diseases.
3: Mechanisms of Regulation of p62 in Autophagy and Implications for Health and Diseases.
4: Molecular Mechanisms Underlying the Role of Autophagy in Neurodegenerative Diseases.
5: Roles of Multiple Types of Autophagy in Neurodegenerative Diseases.
6: Autophagy and Crohn's Disease Towards New Therapeutic Connections.
7: The Role of Autophagy in Atherosclerosis.
8: Treatment of Diabetic Cardiomyopathy through Upregulating Autophagy by Stimulating AMP-Activated Protein Kinase.
9: Hyperglycemia-Associated Oxidative Stress Induces Autophagy: Involvement of the ROS-ERK/JNK-p53 Pathway.
10: Role of Autophagy in Cellular Defense Against Inflammation.
11: Mitophagy Plays a Protective Role in Fibroblasts from Patients with Coenzyme Q10 Deficiency.
12: The Presence of Dioxin in Kidney Cells Induces Cell Death with Autophagy.
13: Cancer.
14: Molecular Mechanisms Underlying the Activation of Autophagy Pathways by Reactive Oxygen Species and their Relevance in Cancer Progression and Therapy.
15: Induction of Autophagic Cell Death by Anticancer Agents.
16: Immunogenicity of Dying Cancer Cells-The Inflammasome Connection: Autophagic Death Arrives on the Scene.
17: Selenite-Mediated Cellular Stress, Apoptosis, and Autophagy in Colon Cancer Cells.
18: Enhancement of Cell Death in High-Grade Glioma Cells: Role of N-(4-Hydroxyphenyl) Retinamide-Induced Autophagy.
19: Cisplatin Exposure of Squamous Cell Carcinoma Cells Leads to Modulation of the Autophagic Pathway.
20: Tumors.
21: Autophagy, Stem Cells, and Tumor Dormancy.
22: Death-Associated Protein Kinase 1 Suppresses Tumor Growth and Metastasis via Autophagy and Apoptosis.
23: TRIM13, Novel Tumor Suppressor: Regulator of Autophagy and Cell Death.
24: Hypoxia-Induced Autophagy Promotes Tumor Cell Survival.
Index.