eBook Antibody Fc:, 1st Edition

  • Published By:
  • ISBN-10: 0123948185
  • ISBN-13: 9780123948182
  • DDC: 571.967
  • Grade Level Range: College Freshman - College Senior
  • 358 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013
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Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.

Table of Contents

Front Cover.
Halftitle Page.
Title Page.
Copyright page.
Short Contents.
List of Contributors.
1: Effector Mechanisms.
2: Antibody-Dependent Cellular Cytotoxicity (ADCC).
3: Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control.
4: Interactions between the Complement System and Fcγ Receptors.
5: Effector Cells.
6: Natural Killer Cells.
7: Phagocytes and Immunoglobulins.
8: B Cells.
9: FcR.
10: Structural Recognition of Immunoglobulins by Fcγ Receptors.
11: FcγRs across Species.
12: Variability of the Fc Domain.
13: Human IgG Subclasses.
14: Antibody Glycosylation.
15: Genetic Associations.
16: Activating and Inhibitory FcγRs in Autoimmune Disorders.
17: Fcγ Receptor Polymorphisms and Susceptibility to Infection.
18: Role of IgG Fc Receptors in Monoclonal Antibody Therapy of Cancer.
19: Evolving Areas.
20: No Mechanism Is an Island.
21: Fc Receptor-Dependent Immunity.
22: Fcγ Receptors as Therapeutic Targets.
23: Fc Protein Engineering.
24: Bacterial Modulation of Fc Effector Functions.
25: Pathogenic Exploitation of Fc Activity.
26: Mechanisms of Immunoglobulin-Mediated Mucus Entrapment of Pathogens at Various Mucosal Surfaces.