eBook Inhibitors of the Ras Superfamily G-proteins, Part A, 1st Edition

  • Volume 1
  • Published By:
  • ISBN-10: 0124169678
  • ISBN-13: 9780124169678
  • DDC: 572.696
  • Grade Level Range: College Freshman - College Senior
  • 364 Pages | eBook
  • Original Copyright 2014 | Published/Released June 2014
  • This publication's content originally published in print form: 2014
  • Price:  Sign in for price



This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

Table of Contents

Front Cover.
Title Page.
Half Title Page.
Copyright Page.
Table of Contents.
1: The Ras Superfamily G-Proteins.
2: NMR Study to Identify a Ligand-Binding Pocket in Ras.
3: The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules.
4: State 1(T) Inhibitors of Activated Ras.
5: Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras–Inhibitor Binding Interface.
6: Development of EHop-016: A Small Molecule Inhibitor of Rac.
7: Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors.
8: Targeting the Dbl and Dock-Family RhoGEFs: A Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways.
9: Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase.
10: A Two-Hybrid Approach to Identify Inhibitors of the RAS–RAF Interaction.
11: Inhibitors of K-Ras Plasma Membrane Localization.
12: Ras Chaperones: New Targets for Cancer and Immunotherapy.
Author Index.
Subject Index.