Biochemistry, 5th Edition

  • Reginald H. Garrett University of Virginia
  • Charles M. Grisham University of Virginia
  • ISBN-10: 1133106293  |  ISBN-13: 9781133106296
  • 1280 Pages
  • Previous Editions: 2009, 1999, 1995
  • © 2013 | Published
  • List Price = $ 427.95
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  • For single copy purchases, visit
  • Newer Edition Available



Succeed in the course with BIOCHEMISTRY. The authors' innovative conceptual and organizing "Essential Questions" framework guides you through course concepts in a way that reveals the beauty and usefulness of biochemistry in the everyday world. Offering a balanced and streamlined presentation, this edition has been updated throughout with new material and revised presentations. This book is integrated with OWL, a powerful online learning system for chemistry that will help you improve your grades and master course concepts.

Features and Benefits

  • Each chapter in this book is framed around an Essential Question that engages students in the material and encourages curiosity about the subject matter.
  • Human Biochemistry essays emphasize the central role of basic biochemistry in medicine and the health sciences with information on clinically important issues such as diet, diabetes, and cardiovascular health.
  • Critical Developments in Biochemistry essays emphasize recent and historical advances in the field, while A Deeper Look essays expand on the text, highlighting selected topics or experimental observations.
  • End-of-chapter summaries review and briefly answer the key questions posed in each section.
  • End-of-chapter summaries review and briefly answer the key questions posed in each section.

Table of Contents

1. The Facts of Life: Chemistry Is the Logic of Biological Phenomena.
2. Water: The Medium of Life.
3. Thermodynamics of Biological Systems.
4. Amino Acids, and the Peptide Bond.
5. Proteins: Their Primary Structure and Biological Functions.
6. Proteins: Secondary, Tertiary, and Quaternary Structure.
7. Carbohydrates and Glycoconjugates of Cell Surfaces.
8. Lipids.
9. Membranes and Membrane Transport.
10. Nucleotides and Nucleic Acids.
11. Structure of Nucleic Acids.
12. Recombinant DNA: Cloning and Creation of Chimeric Genes.
13. Enzymes-Kinetics and Specificity.
14. Mechanisms of Enzyme Action.
15. Enzyme Regulation.
16. Molecular Motors.
17. Metabolism: An Overview.
18. Glycolysis.
19. The Tricarboxylic Acid Cycle.
20. Electron Transport and Oxidative Phosphorylation.
21. Photosynthesis.
22. Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway.
23. Fatty Acid Catabolism.
24. Lipid Biosynthesis.
25. Nitrogen Acquisition and Amino Acid Metabolism.
26. Synthesis and Degradation of Nucleotides.
27. Metabolic Integration and Organ Specialization.
28. DNA Metabolism: Replication, Recombination, and Repair.
29. Transcription and the Regulation of Gene Expression.
30. Protein Synthesis.
31. Completing the Protein Life Cycle: Folding, Processing, and Degradation.
32. The Reception and Transmission of Extracellular Information.

What's New

  • Revised Art and Graphics: To increase the pedagogical effectiveness of the art program and to help students better visualize chemical processes, the book's molecular art has been revised to allow for greater consistency in use of atomic color code and now includes more current PyMOL-based molecular graphics.
  • New End-of-Chapter Material: A new "Things You Should Know" study section has been added to the end-of-chapter material. In addition, new topical headers in the problem sets make it easier to assign problems that pertain to a particular topic.
  • New Coverage: New material has been added on the Ventor Institute's creation of synthetic life; new discussions of protein sectors and metamorphic proteins have been added to Chapter 6; and various free online protein databases have been incorporated throughout the book's narrative.
  • Revised and Updated Coverage: This edition features thoroughly updated coverage of human gene therapy in Chapter 12 and heavily revised coverage of DNA metabolism in Chapter 28.
  • vReorganized Material: Material on reduction potentials and free energy changes in redox reactions has been placed earlier in the book (moved from Chapter 20 to Chapter 3); the discussion of protein techniques was moved from an appendix to Chapter 5 into the chapter proper as an "A Deeper Look" box; and the DNA Sequencing boxed essay is now expanded and incorporated into the Chapter 11 text narrative.
  • Full Integration with OWL (Online Web Learning): For the first time, this book is fully integrated with OWL, a powerful online learning system for chemistry that engages students, assesses performance, and improves learning outcomes. OWL includes parameterized mastery homework assignments correlated to text sections that encourage students to practice multiple questions of the same type with different chemicals, wording, and numbers to ensure their mastery of the underlying chemical concepts. OWL also includes Student Self Assessments, an interactive customizable Cengage YouBook (OWL's multimedia e-book), and an optional Solutions Manual eBook.

Learning Resource Bundles

Choose the textbook packaged with the resources that best meet your course and student needs. Contact your Learning Consultant for more information.

Bundle: Text + Study Guide with Student Solutions Manual and Problems Book

ISBN-10: 1133217036  | ISBN-13: 9781133217039

List Price = $577.95  | CengageBrain Price = $577.95

Bundle: Text + OWL YouBook (24 months) Printed Access Card

ISBN-10:  1133638708  | ISBN-13:  9781133638704

List Price = $446.95

Printed Text + OWL YouBook (6 months) Instant Access Code

ISBN-10:  1133427111  | ISBN-13:  9781133427117

List Price = $439.95

Hardbound Biochemistry, 5th + OWL YouBook with Student Solutions Manual (24 months) Printed Access Card

ISBN-10:  1133848753  | ISBN-13:  9781133848752

List Price = $506.95

Printed Text + Study Guide with Student Solutions Manual and Problems Book + OWL YouBook (24 months) Instant Access Code

ISBN-10:  1133433170  | ISBN-13:  9781133433170

List Price = $597.95

Printed Text + OWL YouBook (24 months) Instant Access Code

ISBN-10:  113342712X | ISBN-13:  9781133427124

List Price = $446.95


All supplements have been updated in coordination with the main title. Select the main title's "About" tab, then select "What's New" for updates specific to title's edition.

For more information about these supplements, or to obtain them, contact your Learning Consultant.

Instructor Supplements

PowerLecture with ExamView®  (ISBN-10: 1133108504 | ISBN-13: 9781133108504)

1This dual-platform digital library and presentation tool provides core text art, photos, and tables in a variety of easily exportable electronic formats. This enhanced CD-ROM also contains easily editable, book-specific PowerPoint® lectures, ExamView® testing software, a test bank in Word and PDF formats, and three sample chapters of the Student Solutions Manual/Study Guide. Every PowerLecture is bound with the Chemistry Multimedia Library, a DVD-ROM containing numerous animations, videos, and tutorials relating to all chemistry sub-disciplines.

Study Guide with Student Solutions Manual and Problems Book  (ISBN-10: 1133108512 | ISBN-13: 9781133108511)

This comprehensive combination resource contains chapter summaries, important definitions, illustrations of major metabolic pathways, self-tests, detailed solutions to all end-of-chapter problems, and additional problems with answers.

List Price = $150.95  | CengageBrain Price = $150.95  | College Bookstore Wholesale Price = $113.25

Student Supplements

Study Guide with Student Solutions Manual and Problems Book  (ISBN-10: 1133108512 | ISBN-13: 9781133108511)

The perfect way to prepare for exams, build problem-solving skills, and get the grade you want! This useful resource reinforces skills with activities and practice problems for each chapter. After completing the end-of-chapter exercises, you can check your answers for the odd-numbered questions.

List Price = $150.95  | CengageBrain Price = $150.95  | College Bookstore Wholesale Price = $113.25

Meet the Author

Author Bio

Reginald H. Garrett

Reginald H. Garrett was educated in the Baltimore city public schools and at the Johns Hopkins University, where he received his Ph.D. in biology in 1968. Since that time, he has conducted research and taught biochemistry courses at the University of Virginia, where he is currently Professor of Biology. He is the author of numerous papers and review articles on biochemical, genetic, and molecular biological aspects of inorganic nitrogen metabolism. His early research focused on the pathway of nitrate assimilation in filamentous fungi. His investigations contributed substantially to our understanding of the enzymology, genetics, and regulation of this major pathway of biological nitrogen acquisition. More recently, he has collaborated in systems approaches to the metabolic basis of nutrition-related diseases. His research has been supported by grants from the National Institutes of Health, the National Science Foundation, and private industry. A member of the American Society for Biochemistry and Molecular Biology, Garrett is a former Fulbright Scholar, was twice Visiting Scholar at the University of Cambridge, and was Invited Professor at the University of Toulouse, France.

Charles M. Grisham

Charles M. Grisham received his B.S. in chemistry from the Illinois Institute of Technology in 1969 and his Ph.D. in chemistry from the University of Minnesota in 1973. Following a postdoctoral appointment at the Institute for Cancer Research in Philadelphia, he became Professor of Chemistry at the University of Virginia, where he teaches biochemistry, introductory chemistry, and physical chemistry. He has authored numerous papers and review articles on active transport of sodium, potassium, and calcium in mammalian systems, on protein kinase C, and on the applications of NMR and EPR spectroscopy to the study of biological systems. His work has been supported by the National Institutes of Health, the National Science Foundation, the Muscular Dystrophy Association of America, the Research Corporation, the American Heart Association and the American Chemical Society. A member of the American Society for Biochemistry and Molecular Biology, Grisham held the Knapp Chair in Chemistry in 1999 at the University of San Diego; was Visiting Scientist at the Aarhus University Institute of Physiology, Aarhus, Denmark, for two years; and received a Research Career Development Award from the National Institutes of Health.